Complement Depletion Facilitates the Infection of Multiple Brain Tumors by an Intravascular, Replication-Conditional Herpes Simplex Virus Mutant

Intravascular routes of administration can provide a means to target gene- and virus-based therapies to multiple tumor foci located within an organ, such as the brain. However, we demonstrate here that rodent plasma inhibits cell transduction by replication-conditional (oncolytic) herpes simplex vir...

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Autores principales: Ikeda, Keiro, Wakimoto, Hiroaki, Ichikawa, Tomotsugu, Jhung, Sarah, Hochberg, Fred H., Louis, David N., Chiocca, E. Antonio
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2000
Materias:
Gene Therapy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC111999/
https://ncbi.nlm.nih.gov/pubmed/10775615
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