Modifications That Stabilize Human Immunodeficiency Virus Envelope Glycoprotein Trimers in Solution

The functional unit of the human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins is a trimer composed of three gp120 exterior glycoproteins and three gp41 transmembrane glycoproteins. The lability of intersubunit interactions has hindered the production and characterization of soluble,...

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Main Authors: Yang, Xinzhen, Florin, Lauren, Farzan, Michael, Kolchinsky, Peter, Kwong, Peter D., Sodroski, Joseph, Wyatt, Richard
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2000
主題:
Structure and Assembly
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC111997/
https://ncbi.nlm.nih.gov/pubmed/10775613
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