Expression of Herpes Simplex Virus ICP47 and Human Cytomegalovirus US11 Prevents Recognition of Transgene Products by CD8(+) Cytotoxic T Lymphocytes

The in vivo persistence of gene-modified cells may be limited by the development of a host immune response to vector-encoded proteins. Herpesviruses evade cytotoxic T-lymphocyte (CTL) recognition by expressing genes which interfere selectively with presentation of viral antigens by class I major his...

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Main Authors: Berger, Carolina, Xuereb, Suzanne, Johnson, David C., Watanabe, Kathe S., Kiem, Hans-Peter, Greenberg, Philip D., Riddell, Stanley R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Gene Therapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC111967/
https://ncbi.nlm.nih.gov/pubmed/10775582
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