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Pathogenesis of Herpes Simplex Virus-Induced Ocular Immunoinflammatory Lesions in B-Cell-Deficient Mice

The role of B cells and humoral immunity in herpes simplex virus (HSV) ocular infections was studied in immunoglobulin μ chain gene-targeted B-cell-deficient mice (μK/O). At doses of virus well tolerated by immunocompetent mice, heightened susceptibility of μK/O mice to herpetic encephalitis as well...

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Autori principali: Deshpande, Shilpa P., Zheng, Mei, Daheshia, Massoud, Rouse, Barry T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC111859/
https://ncbi.nlm.nih.gov/pubmed/10729125
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