Attenuation Markers of a Candidate Dengue Type 2 Vaccine Virus, Strain 16681 (PDK-53), Are Defined by Mutations in the 5′ Noncoding Region and Nonstructural Proteins 1 and 3

The genome of a candidate dengue type 2 (DEN-2) vaccine virus, strain PDK-53, differs from its DEN-2 16681 parent by nine nucleotides. Using infectious cDNA clones, we constructed 18 recombinant 16681/PDK-53 viruses to analyze four 16681-to-PDK-53 mutations, including 5′ noncoding region (5′NC)-57 C...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Butrapet, Siritorn, Huang, Claire Y.-H., Pierro, Dennis J., Bhamarapravati, Natth, Gubler, Duane J., Kinney, Richard M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Vaccines and Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111799/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10708415/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.7.3011-3019.2000
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