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Resistance to Replication of Human Immunodeficiency Virus Challenge in SCID-Hu Mice Engrafted with Peripheral Blood Mononuclear Cells of Nonprogressors Is Mediated by CD8(+) T Cells and Associated with a Proliferative Response to p24 Antigen

High levels of resistance to challenge with human immunodeficiency virus type 1 SF162 were observed in animals engrafted with peripheral blood mononuclear cells of four long-term nonprogressors (LTNPs). Resistance was abrogated by depletion of CD8(+) T cells in vivo and was observed only in LTNPs wi...

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Published in:J Virol
Main Authors: de Quiros, Juan Carlos Lopez Bernaldo, Shupert, W. Lesley, McNeil, Andrew C., Gea-Banacloche, Juan C., Flanigan, Mark, Savage, Ann, Martino, Lisa, Weiskopf, Emma E., Imamichi, Hiromi, Zhang, Yi-Ming, Adelsburger, Joseph, Stevens, Randy, Murphy, Philip M., Zimmerman, Peter A., Hallahan, Claire W., Davey, Richard T., Connors, Mark
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2000
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111681/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10644376/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.4.2023-2028.2000
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