Human Immunodeficiency Virus Type 1- and Cytomegalovirus-Specific Cytotoxic T Lymphocytes Can Persist at High Frequency for Prolonged Periods in the Absence of Circulating Peripheral CD4(+) T Cells

CD4(+) T cells are thought to be critical in the maintenance of virus-specific CD8(+) cytotoxic T-cell (CTL) responses. In human immunodeficiency virus type 1 (HIV-1) infection, a selective decline in HIV-1-specific CTL as the CD4(+) T-cell count decreases has been reported. Using HLA-peptide tetram...

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Main Authors: Spiegel, Hans M. L., Ogg, Graham S., DeFalcon, Elizabeth, Sheehy, Megan E., Monard, Simon, Haslett, Patrick A. J., Gillespie, Geraldine, Donahoe, Sean M., Pollack, Henry, Borkowsky, William, McMichael, Andrew J., Nixon, Douglas F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC111625/
https://ncbi.nlm.nih.gov/pubmed/10623767
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