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Sequential CD4-Coreceptor Interactions in Human Immunodeficiency Virus Type 1 Env Function: Soluble CD4 Activates Env for Coreceptor-Dependent Fusion and Reveals Blocking Activities of Antibodies against Cryptic Conserved Epitopes on gp120

We devised an experimental system to examine sequential events by which the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) interacts with CD4 and coreceptor to induce membrane fusion. Recombinant soluble CD4 (sCD4) activated fusion between effector cells expressing Env and t...

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Udgivet i:J Virol
Principais autores: Salzwedel, Karl, Smith, Erica D., Dey, Barna, Berger, Edward A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2000
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111543/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10590121/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.1.326-333.2000
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