Alpha/Beta Interferons Potentiate Virus-Induced Apoptosis through Activation of the FADD/Caspase-8 Death Signaling Pathway

Interferon (IFN) mediates its antiviral effects by inducing a number of responsive genes, including the double-stranded RNA (dsRNA)-dependent protein kinase, PKR. Here we report that inducible overexpression of functional PKR in murine fibroblasts sensitized cells to apoptosis induced by influenza v...

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Detalhes bibliográficos
Main Authors: Balachandran, Siddharth, Roberts, P. Christopher, Kipperman, Todd, Bhalla, Kapil N., Compans, Richard W., Archer, David R., Barber, Glen N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC111487/
https://ncbi.nlm.nih.gov/pubmed/10627563
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