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Intrinsic Polymerase Activities of UmuD′(2)C and MucA′(2)B Are Responsible for Their Different Mutagenic Properties during Bypass of a T-T cis-syn Cyclobutane Dimer

In wild-type Escherichia coli, translesion replication is largely dependent upon the UmuD′(2)C complex (DNA polymerase V [polV]) or its plasmid-encoded homologs, such as MucA′(2)B. Interestingly, both the efficiency of translesion replication of a T-T cis-syn dimer and the spectra of mutations obser...

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Bibliografiske detaljer
Main Authors: O'Grady, Paul I., Borden, Angela, Vandewiele, Dominique, Ozgenc, Ali, Woodgate, Roger, Lawrence, Christopher W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC111279/
https://ncbi.nlm.nih.gov/pubmed/10735873
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