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Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53

BACKGROUND: We have previously reported that glycerol acts as a chemical chaperone to restore the expression of WAF1 in some human cancer cell lines bearing mutant p53. Since the expression of WAF1 is up-regulated by activated wildtype p53, glycerol appears to restore wtp53 function. The aim of the...

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Autori principali: Ohnishi, Takeo, Ohnishi, Ken, Takahashi, Akihisa
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC111188/
https://ncbi.nlm.nih.gov/pubmed/11965244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-2-6
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