Combining Anthrax Vaccine and Therapy: a Dominant-Negative Inhibitor of Anthrax Toxin Is Also a Potent and Safe Immunogen for Vaccines

Anthrax is caused by the unimpeded growth of Bacillus anthracis in the host and the secretion of toxins. The currently available vaccine is based on protective antigen (PA), a central component of anthrax toxin. Vaccination with PA raises no direct immune response against the bacilli and, being a na...

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Detalhes bibliográficos
Main Authors: Aulinger, Benedikt A., Roehrl, Michael H., Mekalanos, John J., Collier, R. John, Wang, Julia Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1111877/
https://ncbi.nlm.nih.gov/pubmed/15908368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.6.3408-3414.2005
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