Investigation of New Dominant-Negative Inhibitors of Anthrax Protective Antigen Mutants for Use in Therapy and Vaccination

The lethal toxin (LeTx) of Bacillus anthracis plays a key role in the pathogenesis of anthrax. The protective antigen (PA) is a primary part of the anthrax toxin and forms LeTx by combination with lethal factor (LF). Phenylalanine-427 (F427) is crucial for PA function. This study was designed to dis...

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Bibliografiske detaljer
Main Authors: Cao, Sha, Guo, Aizhen, Liu, Ziduo, Tan, Yadi, Wu, Gaobing, Zhang, Chengcai, Zhao, Yaxing, Chen, Huanchun
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Microbial Immunity and Vaccines
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747968/
https://ncbi.nlm.nih.gov/pubmed/19620345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00264-09
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