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Pre-selection of integration sites imparts repeatable transgene expression

Variable gene expression amongst transgenic lines occurs due to copy number and to random associations of incoming DNA with chromosomal elements at the site of integration. Here we describe a method of identifying sites permissive for transgene expression and their use for efficient introduction of...

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Detalhes bibliográficos
Main Authors: Wallace, Helen, Ansell, Ray, Clark, John, McWhir, Jim
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC111032/
https://ncbi.nlm.nih.gov/pubmed/10684942
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