Mutation analysis of the CHK2 gene in breast carcinoma and other cancers

BACKGROUND: Mutations in the CHK2 gene at chromosome 22q12.1 have been reported in families with Li-Fraumeni syndrome. Chk2 is an effector kinase that is activated in response to DNA damage and is involved in cell-cycle pathways and p53 pathways. METHODS: We screened 139 breast tumors for loss of he...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Ingvarsson, Sigurdur, Sigbjornsdottir, Bjarnveig I, Huiping, Chen, Hafsteinsdottir, Sigridur H, Ragnarsson, Gisli, Barkardottir, Rosa B, Arason, Adalgeir, Egilsson, Valgardur, Bergthorsson, Jon TH
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2002
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC111029/
https://ncbi.nlm.nih.gov/pubmed/12052256
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki