A population study of mutations and LOH at breast cancer gene loci in tumours from sister pairs: two recurrent mutations seem to account for all BRCA1/BRCA2 linked breast cancer in Iceland.

The majority of breast cancer in high risk families is believed to result from a mutation in either of two genes named BRCA1 and BRCA2. A germline defect in either gene is usually followed by chromosomal deletion of the normal allele in the tumour. In Iceland two recurrent mutations have been identi...

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Detalhes bibliográficos
Main Authors: Arason, A, Jonasdottir, A, Barkardottir, R B, Bergthorsson, J T, Teare, M D, Easton, D F, Egilsson, V
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1051336/
https://ncbi.nlm.nih.gov/pubmed/9643283
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