Expression of Mycobacterium smegmatis Pyrazinamidase in Mycobacterium tuberculosis Confers Hypersensitivity to Pyrazinamide and Related Amides

A pyrazinamidase (PZase)-deficient pncA mutant of Mycobacterium tuberculosis, constructed by allelic exchange, was used to investigate the effects of heterologous amidase gene expression on the susceptibility of this organism to pyrazinamide (PZA) and related amides. The mutant was highly resistant...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	J Bacteriol
Hauptverfasser:	Boshoff, Helena I. M., Mizrahi, Valerie
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Genetics and Molecular Biology
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110992/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10986252/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.182.19.5479-5485.2000
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!