Expression of Mycobacterium smegmatis Pyrazinamidase in Mycobacterium tuberculosis Confers Hypersensitivity to Pyrazinamide and Related Amides

A pyrazinamidase (PZase)-deficient pncA mutant of Mycobacterium tuberculosis, constructed by allelic exchange, was used to investigate the effects of heterologous amidase gene expression on the susceptibility of this organism to pyrazinamide (PZA) and related amides. The mutant was highly resistant...

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書目詳細資料

發表在:	J Bacteriol
Principais autores:	Boshoff, Helena I. M., Mizrahi, Valerie
格式:	Artigo
語言:	Inglês
出版:	American Society for Microbiology (ASM) 2000
主題:	Genetics and Molecular Biology
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110992/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10986252/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.182.19.5479-5485.2000
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