Expression of Mycobacterium smegmatis Pyrazinamidase in Mycobacterium tuberculosis Confers Hypersensitivity to Pyrazinamide and Related Amides

A pyrazinamidase (PZase)-deficient pncA mutant of Mycobacterium tuberculosis, constructed by allelic exchange, was used to investigate the effects of heterologous amidase gene expression on the susceptibility of this organism to pyrazinamide (PZA) and related amides. The mutant was highly resistant...

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Podrobná bibliografie

Vydáno v:	J Bacteriol
Hlavní autoři:	Boshoff, Helena I. M., Mizrahi, Valerie
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2000
Témata:	Genetics and Molecular Biology
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110992/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10986252/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.182.19.5479-5485.2000
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