Expression of Mycobacterium smegmatis Pyrazinamidase in Mycobacterium tuberculosis Confers Hypersensitivity to Pyrazinamide and Related Amides

A pyrazinamidase (PZase)-deficient pncA mutant of Mycobacterium tuberculosis, constructed by allelic exchange, was used to investigate the effects of heterologous amidase gene expression on the susceptibility of this organism to pyrazinamide (PZA) and related amides. The mutant was highly resistant...

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Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Boshoff, Helena I. M., Mizrahi, Valerie
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Genetics and Molecular Biology
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110992/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10986252/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.182.19.5479-5485.2000
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