Structure of HAP1-PC7 bound to DNA: implications for DNA recognition and allosteric effects of DNA-binding on transcriptional activation

HAP1 is a transcription factor in yeast whose DNA-binding domain has been implicated in directly affecting transcriptional activation. Two separate mutations in the DNA-binding domain, S63G (HAP1-PC7) and S63R (HAP1-18), retain wild-type binding affinity. However, HAP1-PC7 is transcriptionally silen...

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Publicado en:	Nucleic Acids Res
Autores principales:	Lukens, Amanda K., King, Daniel A., Marmorstein, Ronen
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Oxford University Press 2000
Materias:	Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110793/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11024163/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.20.3853
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