Transcriptional repression of BRCA1 by aberrant cytosine methylation, histone hypoacetylation and chromatin condensation of the BRCA1 promoter

BRCA1 expression is repressed by aberrant cytosine methylation in sporadic breast cancer. We hypothesized that aberrant cytosine methylation of the BRCA1 promoter was associated with the transcriptionally repressive effects of histone hypoacetylation and chromatin condensation. To address this quest...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Rice, Judd C., Futscher, Bernard W.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2000
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110706/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10954590/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.17.3233
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