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Selenium Deficiency Reduces the Abundance of mRNA for Se-Dependent Glutathione Peroxidase 1 by a UGA-Dependent Mechanism Likely To Be Nonsense Codon-Mediated Decay of Cytoplasmic mRNA

The mammalian mRNA for selenium-dependent glutathione peroxidase 1 (Se-GPx1) contains a UGA codon that is recognized as a codon for the nonstandard amino acid selenocysteine (Sec). Inadequate concentrations of selenium (Se) result in a decrease in Se-GPx1 mRNA abundance by an uncharacterized mechani...

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Udgivet i:Mol Cell Biol
Principais autores: Moriarty, Patrick M., Reddy, C. Channa, Maquat, Lynne E.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1998
Fag:
Gene Expression
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110672/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9566912/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.5.2932
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