Human CDC6/Cdc18 Associates with Orc1 and Cyclin-cdk and Is Selectively Eliminated from the Nucleus at the Onset of S Phase

In a two-hybrid screen for proteins that interact with human PCNA, we identified and cloned a human protein (hCdc18) homologous to yeast CDC6/Cdc18 and human Orc1. Unlike yeast, in which the rapid and total destruction of CDC6/Cdc18 protein in S phase is a central feature of DNA replication, the tot...

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Bibliographische Detailangaben
Hauptverfasser: Saha, Partha, Chen, Junjie, Thome, Kelly C., Lawlis, Stephanie J., Hou, Zhi-hui, Hendricks, Marvin, Parvin, Jeffrey D., Dutta, Anindya
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1998
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC110655/
https://ncbi.nlm.nih.gov/pubmed/9566895
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