Human CDC6/Cdc18 Associates with Orc1 and Cyclin-cdk and Is Selectively Eliminated from the Nucleus at the Onset of S Phase

In a two-hybrid screen for proteins that interact with human PCNA, we identified and cloned a human protein (hCdc18) homologous to yeast CDC6/Cdc18 and human Orc1. Unlike yeast, in which the rapid and total destruction of CDC6/Cdc18 protein in S phase is a central feature of DNA replication, the tot...

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Podrobná bibliografie
Vydáno v:	Mol Cell Biol
Hlavní autoři:	Saha, Partha, Chen, Junjie, Thome, Kelly C., Lawlis, Stephanie J., Hou, Zhi-hui, Hendricks, Marvin, Parvin, Jeffrey D., Dutta, Anindya
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 1998
Témata:	Cell Growth and Development
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110655/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9566895/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.5.2758
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Human CDC6/Cdc18 Associates with Orc1 and Cyclin-cdk and Is Selectively Eliminated from the Nucleus at the Onset of S Phase

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