Human CDC6/Cdc18 Associates with Orc1 and Cyclin-cdk and Is Selectively Eliminated from the Nucleus at the Onset of S Phase

In a two-hybrid screen for proteins that interact with human PCNA, we identified and cloned a human protein (hCdc18) homologous to yeast CDC6/Cdc18 and human Orc1. Unlike yeast, in which the rapid and total destruction of CDC6/Cdc18 protein in S phase is a central feature of DNA replication, the tot...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Saha, Partha, Chen, Junjie, Thome, Kelly C., Lawlis, Stephanie J., Hou, Zhi-hui, Hendricks, Marvin, Parvin, Jeffrey D., Dutta, Anindya
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1998
Schlagworte:	Cell Growth and Development
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110655/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9566895/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.5.2758
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!