Nuclear Localization of IκBα Is Mediated by the Second Ankyrin Repeat: the IκBα Ankyrin Repeats Define a Novel Class of cis-Acting Nuclear Import Sequences

The ability of the IκBα protein to sequester dimeric NF-κB/Rel proteins in the cytoplasm provides an effective mechanism for regulating the potent transcriptional activation properties of NF-κB/Rel family members. IκBα can also act in the nucleus as a postinduction repressor of NF-κB/Rel proteins. T...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Sachdev, Shrikesh, Hoffmann, Alexander, Hannink, Mark
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1998
Assuntos:	Transcriptional Regulation
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110632/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9566872/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.5.2524
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