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Targeted Recombination within the Spike Gene of Murine Coronavirus Mouse Hepatitis Virus-A59: Q159 Is a Determinant of Hepatotropism

Previous studies of a group of mutants of the murine coronavirus mouse hepatitis virus (MHV)-A59, isolated from persistently infected glial cells, have shown a strong correlation between a Q159L amino acid substitution in the S1 subunit of the spike gene and a loss in the ability to induce hepatitis...

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Autores principales: Leparc-Goffart, Isabelle, Hingley, Susan T., Chua, Ming Ming, Phillips, Joanna, Lavi, Ehud, Weiss, Susan R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 1998
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC110472/
https://ncbi.nlm.nih.gov/pubmed/9811696
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