Targeted Recombination within the Spike Gene of Murine Coronavirus Mouse Hepatitis Virus-A59: Q159 Is a Determinant of Hepatotropism

Previous studies of a group of mutants of the murine coronavirus mouse hepatitis virus (MHV)-A59, isolated from persistently infected glial cells, have shown a strong correlation between a Q159L amino acid substitution in the S1 subunit of the spike gene and a loss in the ability to induce hepatitis...

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Pubblicato in:	J Virol
Autori principali:	Leparc-Goffart, Isabelle, Hingley, Susan T., Chua, Ming Ming, Phillips, Joanna, Lavi, Ehud, Weiss, Susan R.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Viral Pathogenesis and Immunity
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110472/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9811696/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.12.9628-9636.1998
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