Inhibition of Human Immunodeficiency Virus Type 1 Virion Entry by Dominant-Negative Hck

To study the role of Src family tyrosine kinases in infection with human immunodeficiency virus type 1 (HIV-1), we constructed an Hck mutant, HckN, that hinders signaling from wild-type Hck. HIV-1 produced in HckN-expressing cells was significantly less infectious to HeLa–CD4–LTR–β-gal (MAGI) cells...

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Detalhes bibliográficos
Main Authors: Tokunaga, Kenzo, Kiyokawa, Etsuko, Nakaya, Mie, Otsuka, Naomi, Kojima, Asato, Kurata, Takeshi, Matsuda, Michiyuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Viral Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC110455/
https://ncbi.nlm.nih.gov/pubmed/9621101
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