Papillomavirus Assembly Requires Trimerization of the Major Capsid Protein by Disulfides between Two Highly Conserved Cysteines

We have used viruslike particles (VLPs) of human papillomaviruses to study the structure and assembly of the viral capsid. We demonstrate that mutation of either of two highly conserved cysteines of the major capsid protein L1 to serine completely prevents the assembly of VLPs but not of capsomers,...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Sapp, Martin, Fligge, Claudia, Petzak, Ingrid, Harris, J. Robin, Streeck, Rolf E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Animal Viruses
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110432/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9621087/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.7.6186-6189.1998
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