Papillomavirus Assembly Requires Trimerization of the Major Capsid Protein by Disulfides between Two Highly Conserved Cysteines

We have used viruslike particles (VLPs) of human papillomaviruses to study the structure and assembly of the viral capsid. We demonstrate that mutation of either of two highly conserved cysteines of the major capsid protein L1 to serine completely prevents the assembly of VLPs but not of capsomers,...

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הוצא לאור ב:	J Virol
Principais autores:	Sapp, Martin, Fligge, Claudia, Petzak, Ingrid, Harris, J. Robin, Streeck, Rolf E.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	American Society for Microbiology (ASM) 1998
נושאים:	Animal Viruses
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110432/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9621087/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.7.6186-6189.1998
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