Infection with Cytotoxic T-Lymphocyte Escape Mutants Results in Increased Mortality and Growth Retardation in Mice Infected with a Neurotropic Coronavirus

C57BL/6 mice infected with mouse hepatitis virus strain JHM (MHV-JHM) develop a chronic demyelinating encephalomyelitis several weeks after inoculation. Previously, we showed that mutations in the immunodominant CD8 T-cell epitope (S-510-518) could be detected in nearly all samples of RNA and virus...

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Pubblicato in:	J Virol
Autori principali:	Pewe, Lecia, Xue, Shurong, Perlman, Stanley
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Viral Pathogenesis and Immunity
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110395/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9621053/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.7.5912-5918.1998
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