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Antiapoptotic Activity of the Herpesvirus Saimiri-Encoded Bcl-2 Homolog: Stabilization of Mitochondria and Inhibition of Caspase-3-Like Activity

Viruses have evolved different strategies to interfere with host cell apoptosis. Herpesvirus saimiri (HVS) and other lymphotropic herpesviruses code for proteins that are homologous to the cellular antiapoptotic Bcl-2. In this study HVS-Bcl-2 was stably expressed in the human leukemia cell line Jurk...

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Main Authors: Derfuss, Tobias, Fickenscher, Helmut, Kraft, Michael S., Henning, Golo, Lengenfelder, Doris, Fleckenstein, Bernhard, Meinl, Edgar
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 1998
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC110393/
https://ncbi.nlm.nih.gov/pubmed/9621051
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