The Herpes Simplex Virus U(S)11 Protein Effectively Compensates for the γ(1)34.5 Gene if Present before Activation of Protein Kinase R by Precluding Its Phosphorylation and That of the α Subunit of Eukaryotic Translation Initiation Factor 2

In herpes simplex virus-infected cells, viral γ(1)34.5 protein blocks the shutoff of protein synthesis by activated protein kinase R (PKR) by directing the protein phosphatase 1α to dephosphorylate the α subunit of eukaryotic translation initiation factor 2 (eIF-2α). The amino acid sequence of the γ...

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Publicado en:	J Virol
Autores principales:	Cassady, Kevin A., Gross, Martin, Roizman, Bernard
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1998
Materias:	Virus-Cell Interactions
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110273/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9765401/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.11.8620-8626.1998
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