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The Herpes Simplex Virus U(S)11 Protein Effectively Compensates for the γ(1)34.5 Gene if Present before Activation of Protein Kinase R by Precluding Its Phosphorylation and That of the α Subunit of Eukaryotic Translation Initiation Factor 2

In herpes simplex virus-infected cells, viral γ(1)34.5 protein blocks the shutoff of protein synthesis by activated protein kinase R (PKR) by directing the protein phosphatase 1α to dephosphorylate the α subunit of eukaryotic translation initiation factor 2 (eIF-2α). The amino acid sequence of the γ...

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Detalhes bibliográficos
Main Authors: Cassady, Kevin A., Gross, Martin, Roizman, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC110273/
https://ncbi.nlm.nih.gov/pubmed/9765401
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