Characterization of Wild-Type Adeno-Associated Virus Type 2-Like Particles Generated during Recombinant Viral Vector Production and Strategies for Their Elimination

The pSub201-pAAV/Ad plasmid cotransfection system was developed to eliminate homologous recombination which leads to generation of the wild-type (wt) adeno-associated virus type 2 (AAV) during recombinant vector production. The extent of contamination with wt AAV has been documented to range between...

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Autores principales: Wang, Xu-Shan, Khuntirat, Benjawan, Qing, Keyun, Ponnazhagan, Selvarangan, Kube, Dagmar M., Zhou, Shangzhen, Dwarki, Varavani J., Srivastava, Arun
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 1998
Materias:
Gene Therapy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC110186/
https://ncbi.nlm.nih.gov/pubmed/9621003
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