A single intermolecular contact mediates intramolecular stabilization of both RNA and protein

An arginine-rich peptide from the Jembrana disease virus (JDV) Tat protein is a structural “chameleon” that binds bovine immunodeficiency virus (BIV) or HIV TAR RNAs in two different binding modes, with an affinity for BIV TAR even higher than the cognate BIV peptide. We determined the NMR structure...

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Bibliographic Details
Main Authors: Calabro, Valerie, Daugherty, Matthew D., Frankel, Alan D.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1100766/
https://ncbi.nlm.nih.gov/pubmed/15857951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409282102
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