Effects of Mutations in Residues near the Active Site of Human Immunodeficiency Virus Type 1 Integrase on Specific Enzyme-Substrate Interactions

The phylogenetically conserved catalytic core domain of human immunodeficiency virus type 1 (HIV-1) integrase contains elements necessary for specific recognition of viral and target DNA features. In order to identify specific amino acids that determine substrate specificity, we mutagenized phylogen...

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Pubblicato in:	J Virol
Autori principali:	Gerton, Jennifer L., Ohgi, Sharron, Olsen, Mari, DeRisi, Joseph, Brown, Patrick O.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Animal Viruses
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110067/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9573274/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.6.5046-5055.1998
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