Effects of Mutations in Residues near the Active Site of Human Immunodeficiency Virus Type 1 Integrase on Specific Enzyme-Substrate Interactions

The phylogenetically conserved catalytic core domain of human immunodeficiency virus type 1 (HIV-1) integrase contains elements necessary for specific recognition of viral and target DNA features. In order to identify specific amino acids that determine substrate specificity, we mutagenized phylogen...

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Autores principales: Gerton, Jennifer L., Ohgi, Sharron, Olsen, Mari, DeRisi, Joseph, Brown, Patrick O.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 1998
Materias:
Animal Viruses
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC110067/
https://ncbi.nlm.nih.gov/pubmed/9573274
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