Induction of Systemic and Mucosal Immune Responses to Human Immunodeficiency Virus Type 1 by a DNA Vaccine Formulated with QS-21 Saponin Adjuvant via Intramuscular and Intranasal Routes

Induction of mucosal and cell-mediated immunity is critical for development of an effective vaccine against human immunodeficiency virus (HIV). We compared intramuscular and intranasal immunizations with a DNA vaccine encoding env of HIV-1 and evaluated the QS-21 saponin adjuvant for augmentation of...

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Autors principals: Sasaki, Shin, Sumino, Kaharu, Hamajima, Kenji, Fukushima, Jun, Ishii, Norihisa, Kawamoto, Susumu, Mohri, Hiroshi, Kensil, Charlotte Read, Okuda, Kenji
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1998
Matèries:
Viral Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC110054/
https://ncbi.nlm.nih.gov/pubmed/9573261
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