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Identification of Nitric Oxide Synthase 2 as an Innate Resistance Locus against Ectromelia Virus Infection

To assess whether nitric oxide synthase 2 (NOS2) fulfills the criteria of an innate resistance locus against an acute viral infection, we inoculated genetically deficient NOS2−/− mice with virulent ectromelia virus (EV), the causative agent of mousepox. NOS2−/− mice proved highly susceptible to EV y...

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Detalhes bibliográficos
Main Authors: Karupiah, Gunasegaran, Chen, Jian-He, Nathan, Carl F., Mahalingam, Surendran, MacMicking, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC110049/
https://ncbi.nlm.nih.gov/pubmed/9696880
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