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N-Terminal Extension of Human Immunodeficiency Virus Capsid Protein Converts the In Vitro Assembly Phenotype from Tubular to Spherical Particles

Expression of retroviral Gag polyproteins is sufficient for morphogenesis of virus-like particles with a spherical immature protein shell. Proteolytic cleavage of Gag into the matrix (MA), capsid (CA), nucleocapsid (NC), and p6 domains (in the case of human immunodeficiency virus [HIV]) leads to con...

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Udgivet i:J Virol
Principais autores: Gross, Ingolf, Hohenberg, Heinz, Huckhagel, Carola, Kräusslich, Hans-Georg
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1998
Fag:
Animal Viruses
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110021/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9573245/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.6.4798-4810.1998
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