Rotavirus 2/6 Viruslike Particles Administered Intranasally with Cholera Toxin, Escherichia coli Heat-Labile Toxin (LT), and LT-R192G Induce Protection from Rotavirus Challenge

We have shown that rotavirus 2/6 viruslike particles composed of proteins VP2 and VP6 (2/6-VLPs) administered to mice intranasally with cholera toxin (CT) induced protection from rotavirus challenge, as measured by virus shedding. Since it is unclear if CT will be approved for human use, we evaluate...

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Main Authors: O’Neal, Christine M., Clements, John D., Estes, Mary K., Conner, Margaret E.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 1998
主題:
Viral Pathogenesis and Immunity
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC109829/
https://ncbi.nlm.nih.gov/pubmed/9525668
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