Neutralization of Human Immunodeficiency Virus Type 1 by Antibody to gp120 Is Determined Primarily by Occupancy of Sites on the Virion Irrespective of Epitope Specificity

We investigated the relative importance of binding site occupancy and epitope specificity in antibody neutralization of human immunodeficiency virus (HIV) type 1 (HIV-1). The neutralization of a T-cell-line-adapted HIV-1 isolate (MN) was analyzed with a number of monovalent recombinant Fab fragments...

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書目詳細資料

發表在:	J Virol
Principais autores:	Parren, Paul W. H. I., Mondor, Isabelle, Naniche, Denise, Ditzel, Henrik J., Klasse, P. J., Burton, Dennis R., Sattentau, Quentin J.
格式:	Artigo
語言:	Inglês
出版:	American Society for Microbiology (ASM) 1998
主題:	Viral Pathogenesis and Immunity
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109569/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9557629/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.5.3512-3519.1998
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