Spontaneous and Engineered Deletions in the 3′ Noncoding Region of Tick-Borne Encephalitis Virus: Construction of Highly Attenuated Mutants of a Flavivirus

The flavivirus genome is a positive-strand RNA molecule containing a single long open reading frame flanked by noncoding regions (NCR) that mediate crucial processes of the viral life cycle. The 3′ NCR of tick-borne encephalitis (TBE) virus can be divided into a variable region that is highly hetero...

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izdano v:	J Virol
Principais autores:	Mandl, Christian W., Holzmann, Heidemarie, Meixner, Tamara, Rauscher, Susanne, Stadler, Peter F., Allison, Steven L., Heinz, Franz X.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 1998
Teme:	Viral Pathogenesis and Immunity
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109508/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9499069/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.3.2132-2140.1998
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