Adaptation of Tick-Borne Encephalitis Virus to BHK-21 Cells Results in the Formation of Multiple Heparan Sulfate Binding Sites in the Envelope Protein and Attenuation In Vivo

Propagation of the flavivirus tick-borne encephalitis virus in BHK-21 cells selected for mutations within the large surface glycoprotein E that increased the net positive charge of the protein. In the course of 16 independent experiments, 12 different protein E mutation patterns were identified. The...

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Detalhes bibliográficos
Main Authors: Mandl, Christian W., Kroschewski, Helga, Allison, Steven L., Kofler, Regina, Holzmann, Heidemarie, Meixner, Tamara, Heinz, Franz X.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114275/
https://ncbi.nlm.nih.gov/pubmed/11356970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.12.5627-5637.2001
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