Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6
The MDM2 oncoprotein targets the p53 tumor suppressor protein for degradation when the two proteins are expressed in cells. The regulation of p53 levels by MDM2 requires the ability of MDM2 to be exported from the nucleus by utilizing its nuclear export signal (NES). The drug leptomycin B (LMB) bloc...
में बचाया:
| में प्रकाशित: | Mol Cell Biol |
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| मुख्य लेखकों: | , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Taylor & Francis
1998
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109310/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9819415/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.12.7288 |
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