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Mutagenesis of the BH3 Domain of BAX Identifies Residues Critical for Dimerization and Killing

The BCL-2 family of proteins is comprised of proapoptotic as well as antiapoptotic members (S. N. Farrow and R. Brown, Curr. Opin. Genet. Dev. 6:45–49, 1996). A prominent death agonist, BAX, forms homodimers and heterodimerizes with multiple antiapoptotic members. Death agonists have an amphipathic...

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Udgivet i:Mol Cell Biol
Principais autores: Wang, Kun, Gross, Atan, Waksman, Gabriel, Korsmeyer, Stanley J.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1998
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109194/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9742125/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.10.6083
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