Biased Suppression of Hematopoiesis and Multiple Developmental Defects in Chimeric Mice Containing Shp-2 Mutant Cells

Shp-2 is a cytoplasmic tyrosine phosphatase that contains two Src homology 2 (SH2) domains at the N terminus. Biochemical data suggests that Shp-2 acts downstream of a variety of receptor and cytoplasmic tyrosine kinases. A targeted deletion mutation in the N-terminal SH2 (SH2-N) domain results in e...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Qu, Cheng-Kui, Yu, Wen-Mei, Azzarelli, Biagio, Cooper, Scott, Broxmeyer, Hal E., Feng, Gen-Sheng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1998
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109193/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9742124/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.10.6075
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