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Biased Suppression of Hematopoiesis and Multiple Developmental Defects in Chimeric Mice Containing Shp-2 Mutant Cells

Shp-2 is a cytoplasmic tyrosine phosphatase that contains two Src homology 2 (SH2) domains at the N terminus. Biochemical data suggests that Shp-2 acts downstream of a variety of receptor and cytoplasmic tyrosine kinases. A targeted deletion mutation in the N-terminal SH2 (SH2-N) domain results in e...

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Detalhes bibliográficos
Main Authors: Qu, Cheng-Kui, Yu, Wen-Mei, Azzarelli, Biagio, Cooper, Scott, Broxmeyer, Hal E., Feng, Gen-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC109193/
https://ncbi.nlm.nih.gov/pubmed/9742124
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