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Activation of Phosphatidylinositol 3-Kinase Is Sufficient for Cell Cycle Entry and Promotes Cellular Changes Characteristic of Oncogenic Transformation

Using a new inducible form of phosphatidylinositol 3-kinase (PI 3-kinase) we have found that PI 3-kinase activation has the following effects on cell growth and proliferation. (i) Activation of PI 3-kinase was sufficient to promote entry into S phase of the cell cycle within several hours. This was...

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Detalhes bibliográficos
Main Authors: Klippel, Anke, Escobedo, Maria-Amelia, Wachowicz, Matthew S., Apell, Gerald, Brown, Timothy W., Giedlin, Martin A., Kavanaugh, W. Michael, Williams, Lewis T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC109156/
https://ncbi.nlm.nih.gov/pubmed/9742087
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